Introduction: Guided bone regeneration is considered a reliable technique; yet there is a wide range of results
concerning quality and quantity of the regenerated bone. The aim of This study was to assess both the quality
and quantity of the regenerated bone for horizontal augmentation of full arch split mouth maxillary cases using
prebent titanium meshes loaded with bone marrow aspirate mixed with xenograft ( study group)versus
xenograft mixed with autografts in 1:1 ratio ( control group) in a randomized clinical trial.
Method: 8 patients suffered from severe horizontal full arch maxillary deficiency were subjected to guided bone
regeneration. Virtual horizontal bone augmentation was done for the whole maxillary alveolar deficient ridge
using special software to produce virtually augmented stereolithographic plastic models to guide for
prebending of titanium meshes preoperatively. In the study group, prebent meshes were loaded with a mix of
xenograft and Bone marrow aspirate concentrate (BMAC) from the iliac crest. While in the control group the
meshes were loaded with xenograft mixed with autograft only with ratio of 1:1. And meshes were fixed in place
using mini screws
Results: wound healing was uneventful for all patients. CBCT was performed 6 months postoperatively for
each patient who showed a 5.2 mm horizontal bone gain in the study group and 4.3 mm for that of the control.
At the re-entry surgery; core biopsies were retrieved from the regenerated sites using trephine burs for
histomorphometric analysis. a statistically significant higher bone area percent was detected in study group
(47.9 %) as compared to control group (28.5%). A statistically significant higher percentage of mature bone as
detected by Masson trichrome was also detected in study group (67.7 %) as compared to control group
(26.5%).
Conclusion: horizontal bone augmentation using prebent titanium meshes loaded with xenograft with bone
marrow aspirate could be a reliable less morbid technique.